2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

E3 Ligase Ligand-Linker Conjugates Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-133046
    VHL Ligand-Linker Conjugates 17
    VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader. VHL Ligand-Linker Conjugates 17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    VHL Ligand-Linker Conjugates 17
  • HY-161207
    (S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc
    (S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
    (S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc
  • HY-168684
    E3 Ligase Ligand-linker Conjugate 136 2761394-06-1
    E3 Ligase Ligand-linker Conjugate 136 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 136 can be used to synthesize c-Myc inhibitor 7 (HY-148837).
    E3 Ligase Ligand-linker Conjugate 136
  • HY-172593
    E3 Ligase Ligand-linker Conjugate 182
    E3 Ligase Ligand-linker Conjugate 182 is a E3 Ligase Ligand-Linker Conjugates. E3 Ligase Ligand-linker Conjugate 182 consists of a CRBN ligand and a PROTAC linker. E3 Ligase Ligand-linker Conjugate 182 can be used to design PROTACs (such as LZ-07 (HY-172590)).
    E3 Ligase Ligand-linker Conjugate 182
  • HY-156170
    Thalidomide-5-NH-PEG5-NH2 hydrochloride
    Thalidomide-5-NH-PEG5-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-NH-PEG5-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
    Thalidomide-5-NH-PEG5-NH2 hydrochloride
  • HY-131888A
    Pomalidomide-C3-NH2 2093388-20-4
    Pomalidomide-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
    Pomalidomide-C3-NH2
  • HY-159571
    Thalidomide-NH-C5-azacyclohexane-N-Boc 2710222-09-4
    Thalidomide-NH-C5-azacyclohexane-N-Boc is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-NH-C5-azacyclohexane-N-Boc can be used to synthesize XD2-149 (HY-159570).
    Thalidomide-NH-C5-azacyclohexane-N-Boc
  • HY-155263
    Pomalidomide-5-C7-NH2 hydrochloride 3032282-75-7
    Pomalidomide-5-C7-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C7-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
    Pomalidomide-5-C7-NH2 hydrochloride
  • HY-161974
    Adamantan-C-amide-PEG2-C-Br
    Adamantan-C-amide-PEG2-C-Br is a conjugate of a Hyt hydrophobic group and a linker. Adamantan-C-amide-PEG2-C-Br can be used to synthesize ZX782 (HY-161972).
    Adamantan-C-amide-PEG2-C-Br
  • HY-161132
    Lenalidomide 4'-alkyl-C5-azide 2399455-78-6
    Lenalidomide 4'-alkyl-C5-azide is a functionalized cerebellar ligand for PROTAC development that contains an E3 ligand and an alkyl LC5 ligand with terminal azides that can be coupled to a target protein ligand.
    Lenalidomide 4'-alkyl-C5-azide
  • HY-173470
    MTP3 Ligand-linker Conjugate 1
    MTP3 Ligand-linker Conjugate 1 is a conjugate of the MTP3 ligand and the linker. MTP3 Ligand-linker Conjugate 1 can be used for synthesis of PROTAC MTP3 degrade-1 (HY-173467).
    MTP3 Ligand-linker Conjugate 1
  • HY-155267
    Pomalidomide-5-C11-NH2 hydrochloride 98.20%
    Pomalidomide-5-C11-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-5-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
    Pomalidomide-5-C11-NH2 hydrochloride
  • HY-169979
    E3 Ligase Ligand-linker Conjugate 141 2229724-20-1
    E3 Ligase Ligand-linker Conjugate 141 is a conjugate of E3 ubiquitin ligase ligand + Linker, used for the synthesis of PROTAC ER Degrader-12 (HY-160264).
    E3 Ligase Ligand-linker Conjugate 141
  • HY-138858A
    Thalidomide-amido-PEG2-NH2 hydrochloride 2380273-73-2
    Thalidomide-amido-PEG2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-amido-PEG2-NH2 hydrochloride
  • HY-173436
    E3 Ligase Ligand-linker Conjugate 179
    E3 Ligase Ligand-linker Conjugate 179 is an E3 ubiquitinase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 179 can be used to synthesize JV8 (HY-173433).
    E3 Ligase Ligand-linker Conjugate 179
  • HY-134985A
    Thalidomide-NH-PEG1-NH2 diTFA 2768514-19-6
    Thalidomide-NH-PEG1-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-NH-PEG1-NH2 diTFA
  • HY-161131
    Lenalidomide 4'-alkyl-C3-azide 2399455-71-9
    Lenalidomide 4'-alkyl-C3-azide (compound 4a) is a click chemical modified Lenalidomide (HY-A0003) that can be used to synthesize PROTACs. Lenalidomide is an orally active immunomodulator and a ligand for the ubiquitin E3 ligase cereblon (CRBN). Lenalidomide 4'-alkyl-C3-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition reactions (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Lenalidomide 4'-alkyl-C3-azide
  • HY-W584522
    Thalidomide-4-NH-PEG1-COO(t-Bu) 2140807-19-6
    Thalidomide-4-NH-PEG1-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-4-NH-PEG1-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG1-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
    Thalidomide-4-NH-PEG1-COO(t-Bu)
  • HY-162840
    Thalidomide-azetidin-3-one 2770869-33-3
    Thalidomide-azetidin-3-one is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-azetidin-3-one can be used to synthesize PROTAC PD-L1 degrader-2 (HY-162816).
    Thalidomide-azetidin-3-one
  • HY-176138
    E3 Ligase Ligand-linker Conjugate 185 3030500-92-3
    E3 Ligase Ligand-linker Conjugate 185 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 185 can be used to synthesize RP03707 (HY-176134).
    E3 Ligase Ligand-linker Conjugate 185
Cat. No. Product Name / Synonyms Application Reactivity
E3 Ligase Ligand-Linker Conjugates Isoform Comparison

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